4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

Base Information

Chemical Name:4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine
CAS No.:1443153-22-7
Molecular Formula:C₁₉H₂₄N₄S
Molecular Weight:340.492
Hs Code.:

Synonyms:4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

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Chemical Property of 4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

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Technology Process of 4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

There total 7 articles about 4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1443153-41-0
tert-butyl 2-benzyl-4-thiomorpholino-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate

: 1443153-22-7
4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.02.020

Reference yield:

: 141642-82-2
5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 1443153-22-7
4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 24 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 10 h / 20 °C / Inert atmosphere

With pyridine; sodium ethanolate; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.02.020

Reference yield:

: 1023953-97-0
tert-butyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-3H-pyrimido[4,5-d]azepine-7(4H)-carboxylate

: 1443153-22-7
4-(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-yl)thiomorpholine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: acetonitrile / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 10 h / 20 °C / Inert atmosphere

With pyridine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.02.020