Benzonitrile, 5-amino-2-fluoro-4-hydroxy- (9CI)

Base Information

• Chemical Name: Benzonitrile, 5-amino-2-fluoro-4-hydroxy- (9CI)
• CAS No.: 388091-38-1
• Molecular Formula: C7H5 F N2 O
• Molecular Weight: 152.128
• Mol file: 388091-38-1.mol

Synonyms:2-Amino-4-cyano-5-fluorophenol;5-Amino-2-fluoro-4-hydroxybenzonitrile

Chemical Property of Benzonitrile, 5-amino-2-fluoro-4-hydroxy- (9CI)

Chemical Property:

• PSA: 70.04000
• LogP: 1.56638

Purity/Quality:

99%+ ^*data from raw suppliers

5-Amino-2-fluoro-4-hydroxy-benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzonitrile, 5-amino-2-fluoro-4-hydroxy- (9CI)

There total 2 articles about Benzonitrile, 5-amino-2-fluoro-4-hydroxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-hydroxy-5-nitrobenzonitrile (1134198-38-1) → 5-amino-2-fluoro-4-hydroxybenzonitrile (388091-38-1)

Guidance literature:

With hydrogen; In ethanol; at 20 ℃;

Reference yield:

2-fluoro-4-hydroxybenzonitrile (82380-18-5) → 5-amino-2-fluoro-4-hydroxybenzonitrile (388091-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; sulfuric acid / 0.17 h / 65 °C

1.2: 2 h / 65 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 6.5 h / 10 - 35 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran;

Reference yield: 10.0%

5-amino-2-fluoro-4-hydroxybenzonitrile (388091-38-1) + 2-(m-trifluoromethylbenzyl) butanoic acid chloride (388091-37-0) → 2-(5-cyano-6-fluorobenzoxazol-2-yl)-1-(m-trifluoromethylphenyl)butane

Guidance literature:

With toluene-4-sulfonic acid; In xylene; for 8h; Heating / reflux;

upstream raw materials:

2-fluoro-4-hydroxy-5-nitrobenzonitrile

2-fluoro-4-hydroxybenzonitrile