Technology Process of 8-fluoro-4-methylumbelliferyl 2,3,4-tri-O-acetyl-6-O-((18)O)benzoyl-β-D-(6-(18)O)-galactopyranoside
There total 12 articles about 8-fluoro-4-methylumbelliferyl 2,3,4-tri-O-acetyl-6-O-((18)O)benzoyl-β-D-(6-(18)O)-galactopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
1.2: 2 h / Inert atmosphere
2.1: methanesulfonic acid / 2 h / 20 °C
3.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 1.5 h
With
tetrabutylammomium bromide; boron tribromide; sodium hydroxide;
In
methanesulfonic acid; dichloromethane; water;
DOI:10.1021/ja109199p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 7 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C
3.2: 4 - 20 °C
4.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
4.2: 2 h / Inert atmosphere
5.1: methanesulfonic acid / 2 h / 20 °C
6.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 1.5 h
With
hydrogenchloride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; boron tribromide; sodium hydroxide; sodium nitrite;
In
methanol; methanesulfonic acid; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja109199p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 7 h / 20 °C
2.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C
2.2: 4 - 20 °C
3.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: methanesulfonic acid / 2 h / 20 °C
5.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 1.5 h
With
hydrogenchloride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; boron tribromide; sodium hydroxide; sodium nitrite;
In
methanesulfonic acid; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja109199p
