(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

Base Information

Chemical Name:(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol
CAS No.:956282-06-7
Molecular Formula:C₂₅H₂₁F₃N₂O
Molecular Weight:422.45
Hs Code.:

Synonyms:(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

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Technology Process of (cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

There total 7 articles about (cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956274-94-5
(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol

: 956282-06-7
(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 120h; Under 60 W light bulb;

Reference yield:

: 2-[2-(2-(4-trifluoromethyl)phenylethynyl-1H-benzoimidazol-5-yl)phenyl]propan-2-ol

: 956282-06-7
(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

Guidance literature:: With Lindlar's catalyst; In ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;
DOI:10.1021/acs.jmedchem.5b00132

Reference yield:

: 4-bromo-1,2-phenylenediamine dihydrochloride

: 956282-06-7
(cis)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzoimidazol-5-yl}phenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: ethylene glycol / 5 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 1 h / 150 °C

3: Lindlar's catalyst / ethyl acetate / 18 h / 20 °C / 760.05 Torr

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; ethylene glycol; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00132