3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Base Information

Chemical Name:3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide
CAS No.:1181766-57-3
Molecular Formula:C₃₀H₃₅Cl₂N₅O₂
Molecular Weight:568.546
Hs Code.:

Synonyms:3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Suppliers and Price of 3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

There total 4 articles about 3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181767-92-9
C₂₃H₃₂ClN₅O

: 535-80-8
3-chlorobenzoate

: 1181766-57-3
3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; at 20 ℃; for 3h;

Reference yield:

: 1181767-61-2
C₁₅H₂₂N₄O₄

: 1181766-57-3
3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C / 1810.07 Torr

3: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; diisopropyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 3644-18-6
N-(2-(dimethylamino)ethyl)piperazine

: 1181766-57-3
3-(3-chloro-benzoylamino)-N-[2-(4-chloro-phenyl)-ethyl]-4-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 2 h / 100 °C

2: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 20 °C

3: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C / 1810.07 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; diisopropyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;