Technology Process of C24H31F3O5Si
There total 1 articles about C24H31F3O5Si which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl [3-(3-(trifluoromethyl)phenoxy)-2-oxopropyl]phosphonate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
Inert atmosphere;
(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
- Guidance literature:
-
C24H31F3O5Si;
With
B-chlorodiisopinocampheylborane;
In
tetrahydrofuran; n-heptane;
at -30 - -25 ℃;
Inert atmosphere;
With
methanol; sodium hydrogencarbonate;
In
tetrahydrofuran; n-heptane;
at 20 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: (-)-diisopinocamphenylborane chloride / n-heptane; tetrahydrofuran / 5 h / -30 - -25 °C / Inert atmosphere
1.2: 10 h / 20 °C
2.1: 1H-imidazole / dichloromethane / 18 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere
3.2: -30 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4.2: 3.25 h / 0 - 20 °C
5.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C
5.2: pH 6.8 / Aqueous phosphate buffer
6.1: Novozym 435 / 18 h / 30 °C
With
1H-imidazole; hydrogenchloride; potassium tert-butylate; diisobutylaluminium hydride; (-)-diisopinocamphenylborane chloride;
Novozym 435;
In
tetrahydrofuran; hexane; n-heptane; dichloromethane; water;
![(3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde](/Databaselist/images/loading.webp)
