DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid

Base Information

• Chemical Name: DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid
• CAS No.: 82267-44-5
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 82267-44-5.mol

Synonyms:DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid

Chemical Property of DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid

There total 3 articles about DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

<2-(p-methoxyphenyl)ethyl>(acetamido)malonic acid (82267-42-3) → DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid (82267-44-5)

Guidance literature:

In xylene; for 2h; Heating;

DOI:10.1246/bcsj.55.918

Reference yield:

4-methoxyphenethyl bromide (14425-64-0) → DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid (82267-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 27 percent / Na / ethanol / 8 h / Heating

2: 78 percent / 2 M aq. NaOH / ethanol / 72 h / 38 °C

3: 77 percent / xylene / 2 h / Heating

With sodium hydroxide; sodium; In ethanol; xylene;

DOI:10.1246/bcsj.55.918

Reference yield:

2-(4-Methoxyphenyl)ethanol (702-23-8) → DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid (82267-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / PBr₃

2: 27 percent / Na / ethanol / 8 h / Heating

3: 78 percent / 2 M aq. NaOH / ethanol / 72 h / 38 °C

4: 77 percent / xylene / 2 h / Heating

With sodium hydroxide; sodium; phosphorus tribromide; In ethanol; xylene;

DOI:10.1246/bcsj.55.918

upstream raw materials:

<2-(p-methoxyphenyl)ethyl>(acetamido)malonic acid

4-methoxyphenethyl bromide

2-(4-Methoxyphenyl)ethanol

Downstream raw materials:

(S)-homotyrosine

(R)-2-Acetylamino-4-(4-methoxy-phenyl)-butyric acid

O-methyl-L-homotyrosine

DL-2-amino-4-(p-methoxyphenyl)butanoic acid

Refernces

• 1、 Kosui, Nobuo,Waki, Michinori,Kato, Tetsuo,Izumiya, Nobuo. "PREPARATION OF HOMOLOGS OF L-2-AMINO-5-(p-METOXYPHENYL)PENTANOIC ACID". . p. 918 - 920. Retrieved 2007/10/02.