(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

Base Information

Chemical Name:(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate
CAS No.:1421785-59-2
Molecular Formula:C₃₂H₃₁FN₄O₆
Molecular Weight:586.62
Hs Code.:

Synonyms:(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

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Chemical Property of (E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

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Technology Process of (E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

There total 9 articles about (E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1421784-94-2
(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

: 1421785-58-1
tert-butyl methyl[2-(2-nitrophenylamino)-2-oxoethyl]carbamate

: 1421785-59-2
(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 36h; Cooling with ice;

Reference yield:

: 1421787-80-5
2-(8-bromo-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

: 1421785-59-2
(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 3.75 h / 50 - 70 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 3 h / 60 °C

3: 2,6-dimethylpyridine; Methanesulfonic anhydride; lithium bromide / tetrahydrofuran / 13 h / 20 °C

4: sodium hydride / tetrahydrofuran / 36 h / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; lithium borohydride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium hydride; caesium carbonate; lithium bromide; Methanesulfonic anhydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1421787-81-6
propyl 11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepine-8-carboxylate

: 1421785-59-2
(E)-tert-butyl 2-({[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}(2-nitrophenyl)amino)-2-oxoethyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran / 3 h / 60 °C

2: 2,6-dimethylpyridine; Methanesulfonic anhydride; lithium bromide / tetrahydrofuran / 13 h / 20 °C

3: sodium hydride / tetrahydrofuran / 36 h / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; lithium borohydride; sodium hydride; lithium bromide; Methanesulfonic anhydride; In tetrahydrofuran;