(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran

Base Information

• Chemical Name: (2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran
• CAS No.: 1185581-31-0
• Molecular Formula: C₂₅H₃₂O₆
• Molecular Weight: 428.525
• Mol file: 1185581-31-0.mol

Synonyms:(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran

Chemical Property of (2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran

There total 1 articles about (2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]tetrahydropyran (934219-78-0) → (2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran (1185581-31-0)

Guidance literature:

(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]tetrahydropyran; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate;

DOI:10.1271/bbb.80536

Reference yield: 35.0%

(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran (1185581-31-0) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → (2R,3S,5S)-3-(3,4-dimethoxycinnamyl)-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]tetrahydropyran

Guidance literature:

With lithium acetate; copper diacetate; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1271/bbb.80536

upstream raw materials:

(2R,3S,5S)-3-allyl-2-(3,4-dimethoxyphenyl)-5-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]tetrahydropyran