FMOC-D-DAB(ALOC)-OH

Base Information

• Chemical Name: FMOC-D-DAB(ALOC)-OH
• CAS No.: 387824-78-4
• Molecular Formula: C₂₃H₂₄N₂O₆
• Molecular Weight: 424.453
• Hs Code.: 2924299090
• Mol file: 387824-78-4.mol

Synonyms:Butanoicacid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[[(2-propenyloxy)carbonyl]amino]-,(2R)- (9CI)

Chemical Property of FMOC-D-DAB(ALOC)-OH

Chemical Property:

• PSA: 113.96000
• LogP: 4.06240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

N-alpha-Fmoc-Nγ-allyloxycarbonyl-D-2,4-diaminobutyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-DAB(ALOC)-OH

There total 3 articles about FMOC-D-DAB(ALOC)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-(3-fluoren-9-ylmethoxycarbonyl)-4-[2-(allyloxycarbonylamino)ethyl]-5-oxazolidinone (918428-73-6) → (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(prop-2-enoxycarbonylamino)butanoic acid (204316-32-5,387824-78-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; Heating;

DOI:10.1080/00397910600772827

Reference yield:

9H-9-fluorenylmethyl (4S)-4-(3-azido-2-oxopropyl)-5-oxo-1,3-oxazolone-3-carboxylate (918428-66-7) → (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(prop-2-enoxycarbonylamino)butanoic acid (204316-32-5,387824-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / toluene / 0.25 h / microwave irradiation

2: 84 percent / LiOH / tetrahydrofuran / Heating

With lithium hydroxide; In tetrahydrofuran; toluene;

DOI:10.1080/00397910600772827

Reference yield:

Nα-Fmoc-Glu-5-oxazolidinone (159530-17-3) → (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(prop-2-enoxycarbonylamino)butanoic acid (204316-32-5,387824-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / N-methylmorpholine; IBC-Cl; NaN₃ / tetrahydrofuran / 0.5 h / -10 °C

2: 93 percent / toluene / 0.25 h / microwave irradiation

3: 84 percent / LiOH / tetrahydrofuran / Heating

With 4-methyl-morpholine; lithium hydroxide; sodium azide; In tetrahydrofuran; toluene;

DOI:10.1080/00397910600772827

upstream raw materials:

(S)-(3-fluoren-9-ylmethoxycarbonyl)-4-[2-(allyloxycarbonylamino)ethyl]-5-oxazolidinone

9H-9-fluorenylmethyl (4S)-4-(3-azido-2-oxopropyl)-5-oxo-1,3-oxazolone-3-carboxylate

N^α-Fmoc-Glu-5-oxazolidinone

Downstream raw materials:

C₂₃H₂₇F₃N₄O₃

C₂₃H₂₇F₃N₄O₃

(2S)-4-[[(2,4-dimethylphenyl)methyl]amino]-2-[[[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]-butanamide

Refernces