(R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate

Base Information

• Chemical Name: (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate
• CAS No.: 144317-74-8
• Molecular Formula: C₂₇H₃₁F₂N₅O₂
• Molecular Weight: 495.572
• Mol file: 144317-74-8.mol

Synonyms:(R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate

Chemical Property of (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate

There total 2 articles about (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(1R)-1-phenylethyl isocyanate (33375-06-3) + 4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)butanol (105565-56-8) → (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate (144317-74-8)

Guidance literature:

In benzene; for 144h;

DOI:10.1021/jm00102a002

Reference yield:

BMY 14786 (99931-58-5) → (R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate (144317-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride / ethanol

2: 72 percent / benzene / 144 h

With sodium tetrahydroborate; In ethanol; benzene;

DOI:10.1021/jm00102a002

Reference yield: 75.0%

(R,R)-4-<4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl>-1-(4-fluorophenyl)butyl (1-phenethyl)carbamate (144317-74-8) → (+)-BMY 14802

Guidance literature:

With trichlorosilane; triethylamine; In toluene; at 10 ℃; for 72h;

DOI:10.1021/jm00102a002

upstream raw materials:

(1R)-1-phenylethyl isocyanate

4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)butanol

BMY 14786