3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

Base Information

Chemical Name:3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene
CAS No.:915097-93-7
Molecular Formula:C₃₀H₃₁F₂NO
Molecular Weight:459.579
Hs Code.:

Synonyms:3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

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Technology Process of 3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

There total 5 articles about 3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 915098-15-6
3-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]oct-2-ene

: 637-59-2
1-Bromo-3-phenylpropane

: 915097-93-7
3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1016/j.bmc.2006.07.051

Reference yield:

: 915098-11-2
8-ethoxycarbonyl-3-hydroxymethyl-8-azabicyclo[3.2.1]oct-2-ene

: 915097-93-7
3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 2 h / 160 °C

2: 70 percent / potassium hydroxide; hydrazine hydrate / ethane-1,2-diol / 3 h / Heating

3: 81 percent / potassium carbonate / dimethylformamide / 24 h / 80 °C

With potassium hydroxide; potassium carbonate; hydrazine hydrate; In ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.07.051

Reference yield:

: 184368-77-2
8-ethoxycarbonyl-8-azabicyclo[3.2.1]oct-2-ene-3-carboxylic acid methyl ester

: 915097-93-7
3-di(4-fluorophenyl)methoxymethyl-8-(3-phenylpropyl)-8-azabicyclo[3.2.1]oct-2-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / lithium aluminum hydride / toluene / 0 °C

2: 80 percent / 2 h / 160 °C

3: 70 percent / potassium hydroxide; hydrazine hydrate / ethane-1,2-diol / 3 h / Heating

4: 81 percent / potassium carbonate / dimethylformamide / 24 h / 80 °C

With potassium hydroxide; lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; In ethylene glycol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.07.051