3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

Base Information

Chemical Name:3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde
CAS No.:135834-01-4
Molecular Formula:C₁₈H₂₂FNO
Molecular Weight:287.377
Hs Code.:

Synonyms:3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

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Chemical Property of 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

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Technology Process of 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

There total 4 articles about 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 135833-79-3
1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

: 135834-01-4
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: With water; toluene-4-sulfonic acid; In acetone;
DOI:10.1021/jm00105a056

Reference yield:

: 104568-95-8
N-<2-(1,3-dioxolan-2-yl)ethyl>-DL-valine methyl ester

: 135834-01-4
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

2: NaOH / methanol; H₂O / 3 h / Heating

3: 89 percent / acetic anhydride / 2 h / Ambient temperature

4: 90 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Heating

5: 71 percent / trifluoroacetic acid, triethylsilane / CH₂Cl₂ / 2 h / 0 °C

6: 66 percent / p-TSA, H₂O / acetone

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; water; acetic anhydride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jm00105a056

Reference yield:

: 135833-80-6
[1-(2-[1,3]Dioxolan-2-yl-ethyl)-2-(4-fluoro-phenyl)-4-hydroxymethyl-5-isopropyl-1H-pyrrol-3-yl]-methanol

: 135834-01-4
3-[2-(4-Fluoro-phenyl)-5-isopropyl-3,4-dimethyl-pyrrol-1-yl]-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / trifluoroacetic acid, triethylsilane / CH₂Cl₂ / 2 h / 0 °C

2: 66 percent / p-TSA, H₂O / acetone

With triethylsilane; water; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1021/jm00105a056