N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

Base Information

Chemical Name:N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide
CAS No.:475112-28-8
Molecular Formula:C₁₉H₃₀N₂O₄
Molecular Weight:350.458
Hs Code.:

Synonyms:N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

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Chemical Property of N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

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Technology Process of N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

There total 2 articles about N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-24-7
acetic anhydride

: 475112-27-7
(R)-2-(3-Azido-propyl)-2-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-4-methyl-cyclohex-3-enone

: 475112-28-8
N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

Guidance literature:: With hydrogen; sodium acetate; Lindlar's catalyst; In ethyl acetate; under 3102.89 Torr;
DOI:10.1016/S0040-4039(02)00878-X

Reference yield:

: 115512-81-7
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-methylbenzene

: 475112-28-8
N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: K; NH₃; t-BuOH

1.2: 75 percent / aq. HCl; methanol

2.1: 91 percent / H₂; NaOAc / Lindlar / ethyl acetate / 3102.89 Torr

With ammonia; hydrogen; sodium acetate; potassium; tert-butyl alcohol; Lindlar's catalyst; In ethyl acetate;
DOI:10.1016/S0040-4039(02)00878-X

Reference yield:

: 475112-28-8
N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide

: 475112-29-9
C₁₉H₂₉N₃O₅

Guidance literature:: N-{3-[(R)-1-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-6-oxo-cyclohex-2-enyl]-propyl}-acetamide; With sodium acetate; dinitrogen tetraoxide; In dichloromethane; at -30 ℃; for 0.5h;

at -10 - 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(02)00878-X