N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide

Base Information

Chemical Name:N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide
CAS No.:186551-48-4
Molecular Formula:C₂₅H₂₃N₃O₃S
Molecular Weight:445.542
Hs Code.:
DSSTox Substance ID:DTXSID401117781

Synonyms:SCHEMBL2328893;DTXSID401117781;186551-48-4;N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide

Suppliers and Price of N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:445.14601278
Heavy Atom Count:32
Complexity:806

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C2=CC=C(C=C2)S(=O)(=O)NC3CCN(C3=O)CC4=CC(=CC=C4)C#N
Isomeric SMILES:CC1=CC(=CC=C1)C2=CC=C(C=C2)S(=O)(=O)N[C@H]3CCN(C3=O)CC4=CC(=CC=C4)C#N

Technology Process of N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide

There total 2 articles about N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-3'-methyl[1,1'-biphenyl]-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186550-17-4
[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester

: 186551-48-4
3'-Methyl-biphenyl-4-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 7.3 g / HCl / ethyl acetate / 4 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate; 1: acidolysis / 2: Condensation;
DOI:10.1021/jm990040h