3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

Base Information

Chemical Name:3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one
CAS No.:937168-08-6
Molecular Formula:C₂₂H₂₄O₉
Molecular Weight:432.427
Hs Code.:

Synonyms:3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

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Chemical Property of 3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

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Technology Process of 3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

There total 5 articles about 3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 937167-98-1
4,5-dimethoxy-2-[(methoxymethoxy)methyl]phenylboronic acid

: 39753-51-0
4-hydroxy-6,7-dimethoxy-2H-chromen-2-one

: 937168-08-6
3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

Guidance literature:: 4,5-dimethoxy-2-[(methoxymethoxy)methyl]phenylboronic acid; With lead(IV) acetate; mercury(II) diacetate; In chloroform; at 40 - 45 ℃; for 1.5h;

4-hydroxy-6,7-dimethoxy-2H-chromen-2-one; With pyridine; In chloroform; at 65 ℃; Further stages.;
DOI:10.1021/jo062592v

Reference yield:

: 54370-00-2
2-bromo-4,5-dimethoxybenzyl alcohol

: 937168-08-6
3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / NaH / tetrahydrofuran / 5 h / 20 - 60 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

3.1: H₂O / tetrahydrofuran; hexane / 20 °C

4.1: Pb(OAc)4 / Hg(OAc)2 / CHCl₃ / 1.5 h / 40 - 45 °C

4.2: 42 percent / pyridine / CHCl₃ / 65 °C

With lead(IV) acetate; n-butyllithium; water; sodium hydride; mercury(II) diacetate; In tetrahydrofuran; hexane; chloroform;
DOI:10.1021/jo062592v

Reference yield:

: C₁₁H₁₇BO₆(C₃H₆)2

: 937168-08-6
3-[4',5'-dimethoxy-2'-(methoxymethoxymethyl)phenyl]-4-hydroxy-6,7-dimethoxychromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂O / tetrahydrofuran; hexane / 20 °C

2.1: Pb(OAc)4 / Hg(OAc)2 / CHCl₃ / 1.5 h / 40 - 45 °C

2.2: 42 percent / pyridine / CHCl₃ / 65 °C

With lead(IV) acetate; water; mercury(II) diacetate; In tetrahydrofuran; hexane; chloroform;
DOI:10.1021/jo062592v