4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

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Chemical Name:4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide
CAS No.:1401461-74-2
Molecular Formula:C₂₄H₂₄N₆O₂S
Molecular Weight:460.56
Hs Code.:

Synonyms:4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

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Chemical Property of 4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

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Technology Process of 4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

There total 7 articles about 4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401462-53-0
(S)-4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

: 1401461-74-2
4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

Guidance literature:: (S)-4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

With ammonia; In dichloromethane; for 3h;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1401461-74-2
4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / zinc / 1,4-dioxane; water / 2 h / 20 °C

2.2: pH 8

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 30 °C

4.1: sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 30 °C

5.2: pH 4

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3 h / 20 °C

6.2: 3 h

With hydrogenchloride; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(S)-2-methylpyrrolidine

: 1401461-74-2
4-{7-[3-Methoxy-5-((S)-2-methyl-pyrrolidin-1-yl)-phenylamino]-thiazolo[5,4-d]pyrimidin-5-yl}-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / zinc / 1,4-dioxane; water / 2 h / 20 °C

2.2: pH 8

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 30 °C

4.1: sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 30 °C

5.2: pH 4

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3 h / 20 °C

6.2: 3 h

With hydrogenchloride; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;