(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide

Base Information

• Chemical Name: (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide
• CAS No.: 1367877-84-6
• Molecular Formula: C₂₄H₂₇FN₂O₇S
• Molecular Weight: 506.552

Synonyms:(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide

Chemical Property of (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide

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Technology Process of (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide

There total 1 articles about (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3,5-difluoro-4-nitro-benzyl)-hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide → (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide (1367877-84-6)

Guidance literature:

With 2-(methylsulfonyl)ethyl alcohol; sodium hydride; In N,N-dimethyl-formamide; oil; at 0 - 5 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm300069y

Reference yield:

(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide (1367877-84-6) → (3S,4S,5R)-3-(4-amino-3-fluoro-5-hydroxybenzyl)-5-((3-(tert-butyl)benzyl)amino)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide dihydrochloride

Guidance literature:

(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-(3-fluoro-5-hydroxy-4-nitro-benzyl)-hexahydro-2H-thiopyrano-[3,4-d]oxazol-2-one 5,5-dioxide; With potassium trimethylsilonate; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; Inert atmosphere;

DOI:10.1021/jm300069y

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