5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Base Information

Chemical Name:5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide
CAS No.:1415835-45-8
Molecular Formula:C₂₃H₂₄FN₇O₃
Molecular Weight:465.487
Hs Code.:

Synonyms:5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

There total 3 articles about 5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400863-24-2
cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine

: 1415836-67-7
5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid

: 1415835-45-8
5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Guidance literature:: 5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 1.5h; Cooling with ice;

cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1415836-66-6
5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

: 1415835-45-8
5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C / Cooling with ice

2.2: 1 h / 20 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; In dichloromethane;

Reference yield:

: 175596-02-8
4-cyano-2-fluoro benzoyl chloride

: 1415835-45-8
5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 20 °C

2.1: water; lithium hydroxide

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C / Cooling with ice

3.2: 1 h / 20 °C

With 2,6-dimethylpyridine; oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; In dichloromethane;