1-(1-Adamantyl)propan-2-amine

Base Information

• Chemical Name: 1-(1-Adamantyl)propan-2-amine
• CAS No.: 39978-69-3
• Molecular Formula: C₁₃H₂₃N
• Molecular Weight: 193.332
• Hs Code.: 2921300090
• DSSTox Substance ID: DTXSID60960474
• ChEMBL ID: CHEMBL4748478
• Mol file: 39978-69-3.mol

Synonyms:2-amino-1-(adamant-1'-yl)propane;adamantylamphetamine

Chemical Property of 1-(1-Adamantyl)propan-2-amine

Chemical Property:

• Refractive Index: 1.583
• PSA: 26.02000
• LogP: 3.64040
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 193.183049738
• Heavy Atom Count: 14
• Complexity: 192

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(1-Adamantyl)propan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC12CC3CC(C1)CC(C3)C2)N

Technology Process of 1-(1-Adamantyl)propan-2-amine

There total 3 articles about 1-(1-Adamantyl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(1-adamantyl)propan-2-one (19835-39-3) → [2-(adamantan-1-yl)-1-methyl]ethylamine (39978-69-3,747357-37-5,765847-70-9,56558-33-9)

Guidance literature:

With formamide; In formic acid; at 165 - 175 ℃; for 20h;

DOI:10.1055/s-2007-983760

Reference yield:

1-Adamantyl-2-propanone oxime (78679-77-3) → [2-(adamantan-1-yl)-1-methyl]ethylamine (39978-69-3,747357-37-5,765847-70-9,56558-33-9)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; PtO₂; In water; acetic acid;

Reference yield:

→ [2-(adamantan-1-yl)-1-methyl]ethylamine (39978-69-3,747357-37-5,765847-70-9,56558-33-9)

Guidance literature:

Aus Keton III u. Ammoniumformiat;

upstream raw materials:

1-(1-adamantyl)propan-2-one

1-Adamantyl-2-propanone oxime

Downstream raw materials:

(2-Adamantan-1-yl-1-methyl-ethyl)-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amine

(2-Adamantan-1-yl-1-methyl-ethyl)-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

[2,2]bipyridinyl

1-(1-Adamantyl)-2-N-benzylaminopropan

Refernces

• 1、 -. "Anorectic adamantane derivatives and method of using the same". . . Retrieved 2008/06/13.