(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one
CAS No.:1615694-08-0
Molecular Formula:C₁₈H₂₂F₃NO₃
Molecular Weight:357.373
Hs Code.:

Synonyms:(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

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Technology Process of (S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

There total 4 articles about (S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₁₅H₁₅F₃O₃

: 168297-86-7
(S)-4-isopropyl-5,5-dimethyloxazolidin-2-one

: 1615694-08-0
(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

Guidance literature:: (S)-4-isopropyl-5,5-dimethyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₅H₁₅F₃O₃; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo500957d

Reference yield:

: C₁₅H₂₆ClNO₅

: 1615694-08-0
(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 48.17 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

3.3: 3 h / 20 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo500957d

Reference yield:

: 779-89-5,67801-07-4
3-(trifluoromethyl)cinnamic acid

: 1615694-08-0
(S)-4-isopropyl-5,5-dimethyl-3-(3-(3-(trifluoromethyl)phenyl)propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

2.3: 3 h / 20 °C / Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran;
DOI:10.1021/jo500957d