Technology Process of (2S,3S,5S,6R,7R)-1,3,5-tris(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-2,6-dimethyloctane
There total 10 articles about (2S,3S,5S,6R,7R)-1,3,5-tris(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-2,6-dimethyloctane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/ol4004838
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 1.5 h / 0 - 55 °C
2.1: triethylamine; dicyclohexylboron chloride / hexane; diethyl ether / 1 h / -78 °C
2.2: 2 h / -78 °C
3.1: tetramethylammonium triacetoxyborohydride / acetonitrile; acetic acid / 20 h / -30 °C
4.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C
With
2,6-dimethylpyridine; dicyclohexylboron chloride; triethylamine; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/ol4004838
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 1.5 h / -78 °C
3.1: triethylamine; dicyclohexylboron chloride / hexane; diethyl ether / 1 h / -78 °C
3.2: 2 h / -78 °C
4.1: tetramethylammonium triacetoxyborohydride / acetonitrile; acetic acid / 20 h / -30 °C
5.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C
With
2,6-dimethylpyridine; diisobutylaluminium hydride; dicyclohexylboron chloride; isopropylmagnesium chloride; triethylamine; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/ol4004838
