(Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride

Base Information

• Chemical Name: (Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride
• CAS No.: 1429896-92-3
• Molecular Formula: C₁₆H₁₇NO₅S
• Molecular Weight: 335.381
• Mol file: 1429896-92-3.mol

Synonyms:(Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride

Chemical Property of (Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride

There total 1 articles about (Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-methoxy-4-methoxylbenzamide (24056-08-4) + p-toluenesulfonyl chloride (98-59-9) → (Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride (1429896-92-3)

Guidance literature:

N-methoxy-4-methoxylbenzamide; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

p-toluenesulfonyl chloride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 1h; stereospecific reaction; Inert atmosphere;

DOI:10.1021/jo400179u

Reference yield:

(Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride (1429896-92-3) → (Z)-O-methyl-4-methoxybenzohydroximoyl iodide

Guidance literature:

With sodium iodide; In sulfolane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo400179u

Reference yield:

(Z)-N,4-dimethoxybenzimidic 4-methylbenzenesulfonic anhydride (1429896-92-3) → (E)-4-methoxybenzophenone O-methyl oxime (1429897-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / sulfolane / 24 h / 80 °C / Inert atmosphere

2: tri tert-butylphosphoniumtetrafluoroborate; potassium carbonate; palladium diacetate / tetrahydrofuran; water / 6 h / 70 °C / Glovebox; Inert atmosphere

With palladium diacetate; potassium carbonate; sodium iodide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; sulfolane; water; 2: |Suzuki Coupling;

DOI:10.1021/jo400179u

upstream raw materials:

N-methoxy-4-methoxylbenzamide

p-toluenesulfonyl chloride

Downstream raw materials:

(E)-4-methoxybenzophenone O-methyl oxime

(Z)-1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-one O-methyl oxime