ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

Base Information

Chemical Name:ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate
CAS No.:1428308-08-0
Molecular Formula:C₂₄H₃₀N₄O₆
Molecular Weight:470.525
Hs Code.:

Synonyms:ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

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Chemical Property of ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

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Technology Process of ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

There total 8 articles about ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1428308-07-9
tert-butyl [6-(3-methoxyphenoxy)-2-(methylsulfanyl)-3,4-dthydroquinolin-3-yl]carbamate

: 4114-31-2
ethylhydrazine carboxylate

: 1428308-08-0
ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

Guidance literature:: In ethanol; for 4h; Reflux;

Reference yield: 44.0%

: C₂₂H₂₆N₂O₄S

: 4114-31-2
ethylhydrazine carboxylate

: 1428308-08-0
ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

Guidance literature:: In ethanol; at 70 ℃; for 4h;
DOI:10.1039/c2md20166f

Reference yield:

: 1428308-04-6
2-bromo-4-(3-methoxyphenoxy)-1-nitrobenzene

: 1428308-08-0
ethyl 2-{3-[(tert-butoxycarbonyl)amino]-6-(3-methoxyphenoxy)-3,4-dihydroquinolin-2(1H)-ylidene}hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; ammonium chloride / tetrahydrofuran; methanol; water / 3 h / 70 °C

2.1: zinc; iodine / N,N-dimethyl-formamide

2.2: 12 h / 60 °C

3.1: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 12 h / Reflux

4.1: potassium carbonate / tetrahydrofuran / 20 h / 15 °C

5.1: ethanol / 4 h / 70 °C

With tetraphosphorus decasulfide; iodine; iron; sodium carbonate; potassium carbonate; ammonium chloride; zinc; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1039/c2md20166f