4-IODO-5-PHENYLISOXAZOLE

Base Information

• Chemical Name: 4-IODO-5-PHENYLISOXAZOLE
• CAS No.: 31329-63-2
• Molecular Formula: C9H6 I N O
• Molecular Weight: 271.057
• Hs Code.: 2934999090
• Mol file: 31329-63-2.mol

Synonyms:4-IODO-5-PHENYLISOXAZOLE

Chemical Property of 4-IODO-5-PHENYLISOXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 2.94620

Purity/Quality:

99%min ^*data from raw suppliers

4-IODO-5-PHENYLISOXAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODO-5-PHENYLISOXAZOLE

There total 3 articles about 4-IODO-5-PHENYLISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(Z)-3-phenylpropiolaldehyde O-methyl oxime (870127-43-8) → 4-iodo-5-phenylisoxazole (31329-63-2)

Guidance literature:

With Iodine monochloride; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1021/ol052027z

Reference yield:

Phenylpropargyl aldehyde (2579-22-8) → 4-iodo-5-phenylisoxazole (31329-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / Na₂SO₄; pyridine / methanol / 20 °C

2: 83 percent / ICl / CH₂Cl₂ / 0.25 h / 20 °C

With pyridine; Iodine monochloride; sodium sulfate; In methanol; dichloromethane;

DOI:10.1021/ol052027z

Reference yield:

→ 4-iodo-5-phenylisoxazole (31329-63-2)

Guidance literature:

5-Phenylisoxazol, I2/Eg./CCl4, HNO3 (D=1.4) (6h, Wasserbad);

upstream raw materials:

(Z)-3-phenylpropiolaldehyde O-methyl oxime

Phenylpropargyl aldehyde

Refernces

• 1、 Waldo, Jesse P.,Larock, Richard C.. "Synthesis of isoxazoles via electrophilic cyclization". . p. 5203 - 5205. Retrieved 2007/10/03.