3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde

Base Information

• Chemical Name: 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde
• CAS No.: 1207453-04-0
• Molecular Formula: C₂₄H₁₇N₃O₃
• Molecular Weight: 395.417
• Mol file: 1207453-04-0.mol

Synonyms:3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde

Chemical Property of 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde

There total 7 articles about 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

8,9-bis(3-(diethoxymethyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one (1207453-03-9) → 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde (1207453-04-0)

Guidance literature:

8,9-bis(3-(diethoxymethyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one; With hydrogenchloride; In water; at 20 ℃; for 2h;

With potassium carbonate; In water; pH=8; Product distribution / selectivity;

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde (1207453-04-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: methanol / 18 h / 0 - 25 °C

4.1: hydrazine hydrate / methanol / 2 h / 40 °C

5.1: hydrogenchloride / water / 3 h / 20 °C

5.2: pH 8

With hydrogenchloride; sodium tetrahydroborate; hydrogen; hydrazine hydrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

4-nitrophthalide (65399-18-0) → 3,3'-(3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8,9-diyl)dibenzaldehyde (1207453-04-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: methanol / 18 h / 0 - 25 °C

3.1: hydrazine hydrate / methanol / 2 h / 40 °C

4.1: hydrogenchloride / water / 3 h / 20 °C

4.2: pH 8

With hydrogenchloride; hydrogen; hydrazine hydrate; palladium 10% on activated carbon; In methanol; water; ethyl acetate;

upstream raw materials:

8,9-bis(3-(diethoxymethyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

3-nitrophthalic acid anhydride

Isophthalaldehyde

3-(diethoxymethyl)benzaldehyde

Downstream raw materials:

8,9-bis(3-((dimethylamino)methyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

8,9-bis(3-((methylamino)methyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one