Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI)

Base Information

• Chemical Name: Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI)
• CAS No.: 385368-06-9
• Molecular Formula: C₇H₇FO₃
• Molecular Weight: 158.129
• Mol file: 385368-06-9.mol

Synonyms:Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI)

Chemical Property of Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI)

Chemical Property:

• PSA: 54.37000
• LogP: 0.38820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI)

There total 1 articles about Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (+)-(1S,5S,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate (321903-56-4) → (1S,5S,6S)-6-Fluoro-2-oxo-bicyclo[3.1.0]hexane-6-carboxylic acid (385368-06-9,385368-01-4,385368-02-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.166667h;

DOI:10.1021/jm000346k

Reference yield:

(1S,5S,6S)-6-Fluoro-2-oxo-bicyclo[3.1.0]hexane-6-carboxylic acid (385368-06-9,385368-01-4,385368-02-5) → (1S,2R,5S,6S)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (260353-63-7,260353-64-8,260353-65-9,321903-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; H₂O / 8.5 h / 35 °C

2: 72 percent / 60percent aq. H₂SO₄ / 144 h / 140 °C

With 60percent aq. H₂SO₄; In ethanol; water;

DOI:10.1021/jm000346k

upstream raw materials:

ethyl (+)-(1S,5S,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate

Downstream raw materials:

(1S,2R,5S,6S)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid