tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate
• CAS No.: 1352204-61-5
• Molecular Formula: C₁₉H₂₅N₃O₃
• Molecular Weight: 343.426
• Mol file: 1352204-61-5.mol

Synonyms:tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-((3-phenylpropanoyloxy)methyl)quinolin-7-yl)piperazine-1-carboxylate (1352204-62-6) → tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate (1352204-61-5) + 3-Phenylpropionic acid (501-52-0)

Guidance literature:

pH=7.4; aq. buffer; Photolysis; Irradiation;

DOI:10.1002/anie.201102948

Reference yield: 80.0%

tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate (1352204-61-5) + hydrocinnamic acid chloride (645-45-4) → tert-butyl 4-(2-((3-phenylpropanoyloxy)methyl)quinolin-7-yl)piperazine-1-carboxylate (1352204-62-6)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

tert-butyl 4-((2-hydroxymethyl)quinolin-7-yl)piperazine-1-carboxylate (1352204-61-5) → C23H25N3O2 (1352204-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; dmap; In 1,4-dioxane; dichloromethane;

upstream raw materials:

tert-butyl 4-(2-((3-phenylpropanoyloxy)methyl)quinolin-7-yl)piperazine-1-carboxylate

Downstream raw materials:

tert-butyl 4-(2-((3-phenylpropanoyloxy)methyl)quinolin-7-yl)piperazine-1-carboxylate

C₂₃H₂₅N₃O₂

Gd⁽³⁺⁾*(CH₂CH₂NCH₂COO)3(CH₂CH₂NCH(COO)CH₂CH₂CON(CH₂)4NC₉H₅NCH₂OCOC₂H₄C₆H₅)^(4-)=GdC₄₂H₅₁N₇O₁₁^(1-)