methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

Base Information

Chemical Name:methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate
CAS No.:878380-60-0
Molecular Formula:C₁₆H₂₀ClF₃N₂O₂
Molecular Weight:364.795
Hs Code.:

Synonyms:methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

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Chemical Property of methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

Chemical Property:

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Technology Process of methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

There total 1 articles about methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-[2-(dimethyl-hydrazono)-3,3,3-trifluoro-propyl]-benzoic acid methyl ester

: 6940-76-7
1-iodo-3-chloro-propane

: 878380-60-0
methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

Guidance literature:: 4-[2-(dimethyl-hydrazono)-3,3,3-trifluoro-propyl]-benzoic acid methyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

1-iodo-3-chloro-propane; In tetrahydrofuran; at -78 - 23 ℃;
DOI:10.1016/j.bmc.2004.11.050

Reference yield: 82.0%

: 878380-60-0
methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

: 105-56-6
ethyl 2-cyanoacetate

: 553681-14-4
methyl 4-{5-cyano-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]-5-(ethoxycarbonyl)pentyl}benzoate

Guidance literature:: ethyl 2-cyanoacetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate; In N,N-dimethyl-formamide; at 25 - 60 ℃; for 16h;
DOI:10.1016/j.bmc.2004.11.050

Reference yield:

: 878380-60-0
methyl 4-{4-chloro-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

: 553681-15-5
methyl 4-{4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-[1-(dimethylhydrazono)-2,2,2-trifluoroethyl]butyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 82 percent / dimethylformamide / 16 h / 25 - 60 °C

2.1: 63 percent / NaOCH₃ / methanol / 24 h / Heating

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.11.050