4-Bromo-2,5-dimethylbenzyl alcohol

Base Information

• Chemical Name: 4-Bromo-2,5-dimethylbenzyl alcohol
• CAS No.: 952303-55-8
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.09
• Mol file: 952303-55-8.mol

Synonyms:(4-bromo-2,5-dimethylphenyl)methanol

Chemical Property of 4-Bromo-2,5-dimethylbenzyl alcohol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2,5-dimethylbenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromo-2,5-dimethylbenzyl alcohol

There total 4 articles about 4-Bromo-2,5-dimethylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bromo-4 dimethyl-2,5 benzaldehyde (88111-74-4) → (4-bromo-2,5-dimethylphenyl)methanol (952303-55-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 1h;

DOI:10.1021/jo070774z

Reference yield:

2,5-dibromo-p-xylene (1074-24-4) → (4-bromo-2,5-dimethylphenyl)methanol (952303-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyl lithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

1.2: 99 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 99 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol; hexane;

DOI:10.1021/jo070774z

Reference yield:

2,5-dimethylbenzyl chloride (824-45-3) → (4-bromo-2,5-dimethylphenyl)methanol (952303-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; bromine

2: aqueous Pb(NO₃)2

With lead(II) nitrate; bromine; iodine;

upstream raw materials:

4-bromo-2,5-dimethylbenzyl chloride

bromo-4 dimethyl-2,5 benzaldehyde

2,5-dibromo-p-xylene

2,5-dimethylbenzyl chloride

Downstream raw materials:

4-bromo-2,5-dimethylbenzyl chloride

7-(2-azidophenyl)-5,8-dimethylisoquinoline

9-methoxyellipticine

ellipticine

Refernces

• 1、 Liu, Ching-Yuan,Knochel, Paul. "Preparation of polyfunctional aryl azides from aryl triazenes. A new synthesis of ellipticine, 9-methoxyellipticine, isoellipticine, and 7-carbethoxyisoellipticine". . p. 7106 - 7115. Retrieved 2008/02/11.