2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester
• CAS No.: 1029432-03-8
• Molecular Formula: C₉H₁₁NO₄S
• Molecular Weight: 229.257
• Mol file: 1029432-03-8.mol

Synonyms:4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid

Chemical Property of 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester

Chemical Property:

• Boiling Point: 377.2±34.0 °C(Predicted)
• PKA: 2.57±0.10(Predicted)
• Density: 1.331±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

4-(tert-Butoxycarbonyl)thiazole-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester

There total 2 articles about 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butyl 2-ethyl thiazole-2,4-dicarboxylate (1023594-54-8) → 4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid (1029432-03-8)

Guidance literature:

4-tert-butyl 2-ethyl thiazole-2,4-dicarboxylate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 50 ℃; for 2h;

With hydrogenchloride; water;

Reference yield:

2-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid (911466-96-1) → 4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid (1029432-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; p-toluenesulfonyl chloride / 19 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C

With pyridine; p-toluenesulfonyl chloride; lithium hydroxide; In tetrahydrofuran; water;

Reference yield:

4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid (1029432-03-8) + 1,2-diamino-benzene (95-54-5) → C15H17N3O3S (1023594-55-9)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 45 - 50 ℃; for 14h;

upstream raw materials:

4-tert-butyl 2-ethyl thiazole-2,4-dicarboxylate

2-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid

Downstream raw materials:

C₁₅H₁₇N₃O₃S

Refernces

• 1、 -. "ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF". Page/Page column 135-136. . Retrieved 2008/12/05.