5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Base Information

Chemical Name:5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole
CAS No.:1182705-96-9
Molecular Formula:C₂₉H₃₉N₃O₄
Molecular Weight:493.646
Hs Code.:

Synonyms:5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

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Chemical Property of 5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

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Technology Process of 5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

There total 4 articles about 5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 110-85-0
piperazine

: 1182705-88-9
5-[2-(6-bromohexyloxy)-4-isopropoxyphenyl]-4-(4-methoxyphenyl)isoxazole

: 1182705-96-9
5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Guidance literature:: In ethanol; for 4h; Reflux;

Reference yield:

: 485-72-3
7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

: 1182705-96-9
5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 3 h / Reflux

2: potassium carbonate; hydroxylamine hydrochloride / ethanol / 24 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 - 70 °C

4: ethanol / Reflux

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.2174/1573406411309050015

Reference yield:

: 1182705-86-7
5-isopropoxy-2-[4-(4-methoxyphenyl)isoxazol-5-yl]phenol

: 1182705-96-9
5-{4-isopropoxy-2-[6-(piperazin-1-yl)hexyloxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 - 70 °C

2: ethanol / Reflux

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.2174/1573406411309050015