5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

Base Information

Chemical Name:5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one
CAS No.:122970-49-4
Molecular Formula:C₃₁H₂₃N₇O₈S
Molecular Weight:653.632
Hs Code.:

Synonyms:5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

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Chemical Property of 5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

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Technology Process of 5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

There total 3 articles about 5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 123002-32-4
5-<<(N,N-dimethylamino)methylene>amino>-7-chloro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)thiazolo<4,5-d>pyrimidin-2(3H)-one

: 122970-49-4
5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm00163a064

Reference yield:

: 30161-97-8
5-aminothiazolo<4,5-d>pyrimidine-2,7(3H,6H)-dione

: 122970-49-4
5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HMDS, (NH₄)2SO₄, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, 16 h

2: 84 percent / thionyl chloride / CH₂Cl₂ / 16 h / 60 °C

3: 67 percent / sodium azide / dimethylformamide / 72 h / Ambient temperature

With ammonium sulfate; thionyl chloride; sodium azide; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a064

Reference yield:

: 122970-39-2
5-amino-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)thiazolo<4,5-d>pyrimidine-2,7(3H,6H)-dione

: 122970-49-4
5-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrazolo<5,1-f>thiazolo<4,5-d>pyrimidin-8(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / thionyl chloride / CH₂Cl₂ / 16 h / 60 °C

2: 67 percent / sodium azide / dimethylformamide / 72 h / Ambient temperature

With thionyl chloride; sodium azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a064