N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Base Information

Chemical Name:N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide
CAS No.:1333127-26-6
Molecular Formula:C₂₇H₂₀Cl₂F₇N₅O₅
Molecular Weight:698.381
Hs Code.:

N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Synonyms:N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

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Chemical Property of N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Chemical Property:

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Technology Process of N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

There total 5 articles about N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333127-23-3
2-[3-(trifluoroacetylamino)propoxy]-4-[trifluoroacetyl-(methyl)amino]-6-fluorobenzoic acid

: 229343-30-0
2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide

: 1333127-26-6
N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 48h;

Reference yield:

: 1333127-20-0
4-(tertbutoxycarbonyl(methyl)amino)-6-fluorosalicylic acid

: 1333127-26-6
N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / 1 h / 110 °C

2: hydrogenchloride; water / ethanol / 2 h

3: 1 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol;

Reference yield:

: 1333127-45-9
4-methylamino-6-fluorosalicylic acid

: 1333127-26-6
N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / 1,4-dioxane; water / 24 h

2: potassium carbonate / 1 h / 110 °C

3: hydrogenchloride; water / ethanol / 2 h

4: 1 h

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;