Technology Process of 1-(2-iodo-3,5-dimethoxyphenyl)-2-(2,4,5-trimethoxyphenyl)ethane
There total 9 articles about 1-(2-iodo-3,5-dimethoxyphenyl)-2-(2,4,5-trimethoxyphenyl)ethane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-iodo-succinimide; trifluoroacetic acid;
In
acetonitrile;
at 50 ℃;
for 8h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.06.054
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
1.2: 8 h / 0 - 20 °C / Inert atmosphere
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere
3.1: palladium diacetate; N,N-dimethyl-formamide; potassium hydroxide / 3 h / 145 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 8 h / 20 °C / 2585.81 Torr
5.1: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 8 h / 50 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; palladium 10% on activated carbon; hydrogen; palladium diacetate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; potassium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; acetonitrile;
1.1: Corey-Fuchs reaction / 1.2: Corey-Fuchs reaction / 2.1: Sonogashira coupling;
DOI:10.1016/j.tet.2011.06.054
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride
2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 8 h / 50 °C / Inert atmosphere
With
N-iodo-succinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; trifluoroacetic acid;
In
acetonitrile;
DOI:10.1016/j.tet.2011.06.054
