Technology Process of 5-[(2R)-5-benzoxy-2-methylpentylsulfanyl]-1-phenyl-1H-tetrazole
There total 7 articles about 5-[(2R)-5-benzoxy-2-methylpentylsulfanyl]-1-phenyl-1H-tetrazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo4006602
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride
2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: tetrahydrofuran / 20 °C / Inert atmosphere
4.1: sodium peroxoborate tetrahydrate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
With
sodium peroxoborate tetrahydrate; tetrabutyl ammonium fluoride; sec.-butyllithium; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; cyclohexane; water;
2.2: |Wittig Olefination;
DOI:10.1021/jo4006602
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 20 °C / Inert atmosphere
3.1: sodium peroxoborate tetrahydrate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
With
sodium peroxoborate tetrahydrate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
In
tetrahydrofuran; water;
1.1: |Julia-Kocienski Olefination;
DOI:10.1021/jo4006602
