3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

Base Information

Chemical Name:3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine
CAS No.:220503-84-4
Molecular Formula:C₃₀H₄₃N₃O₇Si
Molecular Weight:585.773
Hs Code.:

Synonyms:3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

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Chemical Property of 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

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Technology Process of 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

There total 5 articles about 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 220503-65-1
3',5'-O-(di-tert-butylsilanediyl)-2'-C-β-methyl-4-N-benzoylcytidine

: 220503-84-4
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

Guidance literature:: With (1S)-10-camphorsulfonic acid; In dichloromethane; overnight;
DOI:10.1021/jo981329u

Reference yield:

: 26661-13-2
4-N-benzoylcytosine

: 220503-84-4
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

Guidance literature:: Multi-step reaction with 5 steps

1: (NH₄)2SO₄ / Heating

2: 86 percent / SnCl₄ / acetonitrile

3: 94 percent / aq. NaOH / pyridine; methanol / 0.5 h / -20 - -15 °C

4: 95 percent / AgNO₃ / dimethylformamide / 0 deg C to rt

5: 95 percent / 10-camphorsulfonic acid / CH₂Cl₂ / overnight

With ammonium sulfate; sodium hydroxide; (1S)-10-camphorsulfonic acid; tin(IV) chloride; silver nitrate; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo981329u

Reference yield:

: 64339-87-3
N₄,O-bis(trimethylsilyl)-N₄-benzoylcytosine

: 220503-84-4
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tetrahydropyranyl)cytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / SnCl₄ / acetonitrile

2: 94 percent / aq. NaOH / pyridine; methanol / 0.5 h / -20 - -15 °C

3: 95 percent / AgNO₃ / dimethylformamide / 0 deg C to rt

4: 95 percent / 10-camphorsulfonic acid / CH₂Cl₂ / overnight

With sodium hydroxide; (1S)-10-camphorsulfonic acid; tin(IV) chloride; silver nitrate; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo981329u