Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester
CAS No.:345915-37-9
Molecular Formula:C₂₃H₄₂O₄SSi
Molecular Weight:442.736
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Suppliers and Price of Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

There total 9 articles about Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98-59-9
p-toluenesulfonyl chloride

: 345915-36-8
(2S,4S)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexan-1-ol

: 345915-37-9
Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Guidance literature:: With trimethylamine hydrochloride; triethylamine; In toluene;
DOI:10.1016/S0040-4039(01)00205-2

Reference yield:

: 1730-89-8
(S)-4-methylhexanoic acid

: 345915-37-9
Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / EDCl*HCl; DMAP / CH₂Cl₂

2.1: [(c-Hex)2BOTf]2; Et₃N / CH₂Cl₂ / -78 °C

2.3: 90 percent / H₂O₂; buffer / pH 7.0

3.1: imidazole / dimethylformamide

4.1: DIBAl-H / CH₂Cl₂

5.1: 94 percent / Me₃N*HCl; Et₃N / toluene

With 1H-imidazole; dmap; [(c-Hex)2BOTf]2; trimethylamine hydrochloride; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)00205-2

Reference yield:

: 1565-80-6
(2S)-2-methyl-1-butanol

: 345915-37-9
Toluene-4-sulfonic acid (2S,4S)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-hexyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 97 percent / Me₃N*HCl; Et₃N / toluene

2.1: 91 percent / CsF / dimethylformamide

3.1: NaOH / aq. methanol / Saponification

4.1: NaCl / dimethylsulfoxide / 130 °C

5.1: 98 percent / EDCl*HCl; DMAP / CH₂Cl₂

6.1: [(c-Hex)2BOTf]2; Et₃N / CH₂Cl₂ / -78 °C

6.3: 90 percent / H₂O₂; buffer / pH 7.0

7.1: imidazole / dimethylformamide

8.1: DIBAl-H / CH₂Cl₂

9.1: 94 percent / Me₃N*HCl; Et₃N / toluene

With 1H-imidazole; dmap; sodium hydroxide; [(c-Hex)2BOTf]2; trimethylamine hydrochloride; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; cesium fluoride; sodium chloride; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)00205-2