1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

Base Information

Chemical Name:1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one
CAS No.:937026-24-9
Molecular Formula:C₂₅H₂₆FN₃O₃
Molecular Weight:435.498
Hs Code.:

Synonyms:1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

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Chemical Property of 1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

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Technology Process of 1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

There total 2 articles about 1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylbenzoic acid methyl ester

: 937026-11-4
1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one

: 937026-24-9
1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

Guidance literature:: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one; With n-butyllithium; acetic acid; diisopropylamine; In tetrahydrofuran; cyclohexane; for 0.15h; Cooling with ethanol-dry ice;

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylbenzoic acid methyl ester; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; cyclohexane; at -40 ℃; for 1.6h; Product distribution / selectivity; Cooling with ethanol-dry ice;

Reference yield: 74.0%

: 937026-27-2
N,3-dimethoxy-N-methyl-4-(4-methyl-1H-imidazol-1-yl)benzamide

: 937026-11-4
1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one

: 937026-24-9
1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

Guidance literature:: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one; With n-butyllithium; diisopropylamine; In tetrahydrofuran; cyclohexane; at -40 ℃; for 0.4h;

N,3-dimethoxy-N-methyl-4-(4-methyl-1H-imidazol-1-yl)benzamide; In tetrahydrofuran; cyclohexane; at -40 ℃; for 1.8h; Product distribution / selectivity;

Reference yield: 81.0%

: 937026-24-9
1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one

: 870843-42-8,870846-02-9
(E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one

Guidance literature:: 1-[(S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoyl]piperidin-2-one; With sodium tetrahydroborate; In isopropyl alcohol; at 20 ℃; for 12h;

With water; In isopropyl alcohol; toluene; Product distribution / selectivity;