(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

Base Information

Chemical Name:(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol
CAS No.:164592-59-0
Molecular Formula:C₅₂H₉₂O₇S₄Si
Molecular Weight:985.648
Hs Code.:

(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

Synonyms:(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

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Chemical Property of (E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

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Technology Process of (E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

There total 25 articles about (E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 164592-58-9
2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithiane

: 186448-86-2
Triisopropyl-((1R,2R,4S)-2-methoxy-4-{(2R,3S)-3-(4-methoxy-benzyloxy)-2-methyl-4-[2-((E)-(R)-1-methyl-3-(R)-oxiranyl-but-2-enyl)-[1,3]dithian-2-yl]-butyl}-cyclohexyloxy)-silane

: 164592-59-0
(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; pentane; at -78 - -55 ℃; Yield given;
DOI:10.1021/ja963066w

Reference yield:

: 186448-80-6
(E)-(2R,5R)-5-{2-[(2S,3R)-2-(4-Methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-ene-1,2-diol

: 164592-59-0
(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

2: K₂CO₃ / methanol / 1 h / Ambient temperature

3: t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 - -55 °C

With dmap; tert.-butyl lithium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; pentane;
DOI:10.1021/ja963066w

Reference yield:

: 164714-14-1
{(1R,2R,4S)-4-[(2R,3S)-4-{2-[(E)-(R)-3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-but-2-enyl]-[1,3]dithian-2-yl}-3-(4-methoxy-benzyloxy)-2-methyl-butyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

: 164592-59-0
(E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / camphorsulfonic acid / methanol / 2 h / Ambient temperature

2: 85 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

3: K₂CO₃ / methanol / 1 h / Ambient temperature

4: t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 - -55 °C

With dmap; camphor-10-sulfonic acid; tert.-butyl lithium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; pentane;
DOI:10.1021/ja963066w