Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester

Base Information

• Chemical Name: Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester
• CAS No.: 112196-50-6
• Molecular Formula: C₂HF₃O₂*C₄H₉NO₂
• Molecular Weight: 217.145
• Mol file: 112196-50-6.mol

Synonyms:Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester

Chemical Property of Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester

There total 1 articles about Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate (42492-57-9) + trifluoroacetic acid (76-05-1) → Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester (112196-50-6)

Guidance literature:

at 25 ℃; for 0.5h;

DOI:10.1021/jo00238a005

Reference yield:

Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester (112196-50-6) + Nα-Boc-Tyr-D-Met-Phe-OH (100572-39-2) → Boc-Tyr-D-Met-Phe-Sar-OCH3 (108269-49-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; a) 0 deg C, 2 h, b ) RT, 24 h;

DOI:10.1021/jm00392a002

Reference yield:

Trifluoro-acetic acid; compound with methylamino-acetic acid methyl ester (112196-50-6) + C33H45N3O8S → Boc-Tyr-D-Met-Phe-Sar-OCH3 (108269-49-4)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; a) -10 deg C, 1 h, b) from 0 deg C to 10 deg C, 3 h;

DOI:10.1021/jm00392a002

upstream raw materials:

methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate

trifluoroacetic acid

Downstream raw materials:

Boc-Tyr-D-Met-Phe-Sar-OCH₃