8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

Base Information

• Chemical Name: 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine
• CAS No.: 1244954-63-9
• Molecular Formula: C₂₁H₂₂N₆S
• Molecular Weight: 390.512
• Mol file: 1244954-63-9.mol

Synonyms:8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

Chemical Property of 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

There total 3 articles about 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-(ammoniomethyl)phenyl)pyridin-1-ium bis-trifluoroacetate salt + 4-chloro-2-(methylsulfanyl)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazine (1453186-96-3) → 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine (1244954-63-9)

Guidance literature:

With triethylamine; In butan-1-ol; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.08.100

Reference yield: 60.0%

→ 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine (1244954-63-9)

Guidance literature:

Reference yield:

8-isopropyl-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol → 8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine (1244954-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-aniline / 4 h / 0 - 100 °C / Inert atmosphere

2: triethylamine / butan-1-ol / 3 h / 80 °C / Inert atmosphere

With triethylamine; trichlorophosphate; In N,N-dimethyl-aniline; butan-1-ol;

DOI:10.1016/j.ejmech.2018.08.100

upstream raw materials:

4-chloro-2-(methylsulfanyl)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazine

Downstream raw materials:

(R)-2-(1-hydroxybut-2-ylamino)-8-isopropyl-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

(R)-2-(1-hydroxybut-2-ylamino)-8-isopropyl-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine fumarate

8-isopropyl-2-(methylsulfoxyl)-4-[4-(pyridin-3-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

2-(methylsulfoxyl)-8-isopropyl-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine