3,3-bis(4-fluorophenyl)-2-propenonitrile

Base Information

• Chemical Name: 3,3-bis(4-fluorophenyl)-2-propenonitrile
• CAS No.: 50775-35-4
• Molecular Formula: C₁₅H₉F₂N
• Molecular Weight: 241.24
• Mol file: 50775-35-4.mol

Synonyms:3,3-bis(4-fluorophenyl)-2-propenonitrile

Chemical Property of 3,3-bis(4-fluorophenyl)-2-propenonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-bis(4-fluorophenyl)-2-propenonitrile

There total 6 articles about 3,3-bis(4-fluorophenyl)-2-propenonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C18H18F2OSi (1391868-38-4) → 3,3-bis(4-fluorophenyl)-2-propenonitrile (50775-35-4)

Guidance literature:

With iron(III) chloride; toluene-4-sulfonic acid hydrazide; In nitromethane; at 20 - 60 ℃; for 2.25h;

DOI:10.1002/chem.201200763

Reference yield: 86.3%

→ 3,3-bis(4-fluorophenyl)-2-propenonitrile (50775-35-4)

Guidance literature:

Reference yield: 85.0%

3,3-bis(4-fluorophenyl)-3-hydroxypropanenitrile (50775-33-2) → 3,3-bis(4-fluorophenyl)-2-propenonitrile (50775-35-4)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1080/00397910802006388

upstream raw materials:

diethyl 1-cyanomethylphosphonate

4,4'-Difluorobenzophenone

3,3-bis(4-fluorophenyl)-3-hydroxypropanenitrile

ethyl 2-cyano-3,3-bis(4-fluorophenyl)-2-propenoate

Downstream raw materials:

2,2-bis(4-fluorophenyl)cyclopropanenitrile

3,3-bis(4-fluorophenyl)propan-1-amine

3,3-bis(4-fluorophenyl)propionitrile

3,3-bis(4-fluorophenyl)-2-propen-1-amine