p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

Base Information

Chemical Name:p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate
CAS No.:165743-52-2
Molecular Formula:C₂₆H₂₄N₄O₆
Molecular Weight:488.5
Hs Code.:

Synonyms:p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

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Chemical Property of p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

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Technology Process of p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

There total 3 articles about p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165743-51-1
5-methyl-2-phenyl-3-(tri-n-butylstannyl)pyrazole

: p-Nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-oxocarbapenam-3-carboxylate

: 358-23-6
trifluoromethylsulfonic anhydride

: 603-32-7
triphenyl-arsane

: 108-18-9
diisopropylamine

: 135439-84-8
p-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-trifluoromethylsulphonyloxy-carbapen-2-em-3carboxylate

: 165743-52-2
p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

Guidance literature:: With lithium chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; Zinc chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate;

Reference yield:

: 5-methyl-1-phenyl-3-tributylstannanyl-1H-pyrazole

: 135439-84-8
p-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-trifluoromethylsulphonyloxy-carbapen-2-em-3carboxylate

: 165743-52-2
p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

Guidance literature:: With triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium chloride; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.7164/antibiotics.51.210

Reference yield:

: 74288-40-7
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

: 165743-52-2
p-Nitrobenzyl (5R,6S)-6[(1R)-1-hydroxyethyl]-2-(5-methyl-1-phenylpyrazol-3-yl)carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C

2: Ph₃As / ZnCl₂, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C

With triphenyl-arsane; diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1: Addition / 2: Addition;
DOI:10.7164/antibiotics.51.210