(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

Base Information

Chemical Name:(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt
CAS No.:108165-88-4
Molecular Formula:C₂₁H₁₇ClNO₃*Na
Molecular Weight:389.814
Hs Code.:

Synonyms:(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

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Chemical Property of (Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

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Technology Process of (Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

There total 5 articles about (Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108193-18-6
2-{3-[(Z)-2-(7-Chloro-quinolin-2-yl)-1-methyl-vinyl]-phenoxy}-propionic acid methyl ester

: 108165-88-4
(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃; for 2h;
DOI:10.1021/jm00099a011

Reference yield:

: 4965-33-7
2-methyl-7-chloroquinoline

: 108165-88-4
(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, RT, 1 h

2: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, a) -78 deg C, 45 min, b) from -78 deg C to RT, 2.5 h

3: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

4: K₂CO₃ / butan-2-one / 4 h / Heating

5: 10 N aq. NaOH / ethanol / 2 h / 50 °C

With sodium hydroxide; boron tribromide; potassium carbonate; lithium diisopropyl amide; In ethanol; dichloromethane; butanone;
DOI:10.1021/jm00099a011

Reference yield:

: 108193-15-3
7-chloro-2-<(trimethylsilyl)methyl>quinoline

: 108165-88-4
(Z)-D,L-2-{3-[2-(7-chloro-2-quinolinyl)-1-methylethenyl]phenoxy}propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, a) -78 deg C, 45 min, b) from -78 deg C to RT, 2.5 h

2: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

3: K₂CO₃ / butan-2-one / 4 h / Heating

4: 10 N aq. NaOH / ethanol / 2 h / 50 °C

With sodium hydroxide; boron tribromide; potassium carbonate; lithium diisopropyl amide; In ethanol; dichloromethane; butanone;
DOI:10.1021/jm00099a011