5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester
• CAS No.: 917112-59-5
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.278
• Mol file: 917112-59-5.mol

Synonyms:5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Chemical Property of 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

There total 2 articles about 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Benzoylpyridine (5424-19-1) → 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (917112-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / 5 percent Pd-C / aq. ethanol / 36 h / 20 °C / 5171.48 Torr

2: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1002/ejoc.200600558

Reference yield:

3-Benzoyl-1,4,5,6-tetrahydropyridin (42374-33-4) + methyl chloroformate (79-22-1) → 5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (917112-59-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200600558

Reference yield:

5-benzoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (917112-59-5) → 3-benzoyl-piperidine-1-carboxylic acid methyl ester

Guidance literature:

With hydrogen; [Rh((S,S,R,R)-Tangphos)NBD][SbF₆]; In dichloromethane; at 80 ℃; for 72h; under 67229.2 Torr;

DOI:10.1002/ejoc.200600558

upstream raw materials:

3-Benzoyl-1,4,5,6-tetrahydropyridin

methyl chloroformate

3-Benzoylpyridine