Technology Process of (1S,4R,E)-1-isopropyl-4-methyl-2-(nitromethylene)cyclohexane
There total 2 articles about (1S,4R,E)-1-isopropyl-4-methyl-2-(nitromethylene)cyclohexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver(I) nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
1,2-dichloro-ethane;
at 70 ℃;
for 12h;
stereoselective reaction;
Molecular sieve;
DOI:10.1021/ja311942e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / benzene / 1 h / Cooling with ice; Reflux; Inert atmosphere
1.2: 20 °C / Cooling with ice; Inert atmosphere
2.1: silver(I) nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / 1,2-dichloro-ethane / 12 h / 70 °C / Molecular sieve
With
silver(I) nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate;
In
1,2-dichloro-ethane; benzene;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1021/ja311942e