<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

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Chemical Name:<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one
CAS No.:136089-35-5
Molecular Formula:C₁₉H₂₆O₆
Molecular Weight:350.412
Hs Code.:

Synonyms:<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

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Chemical Property of <2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

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Technology Process of <2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

There total 8 articles about <2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 120052-41-7
<2R-<2α(R^*),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2H-pyran-3(6H)-one

: 136089-35-5
<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h;
DOI:10.1021/jo00023a028

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 136089-35-5
<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-BuLi / 1.) THF, 0 deg C, 4 h, 2.) r.t., 10 h

2: n-Bu₄NF / tetrahydrofuran / 8 h / Ambient temperature

3: 91 percent / t-BuOOH, VO(acac)2 / CH₂Cl₂; 2,2,4-trimethyl-pentane / Ambient temperature

4: 67 percent / Ag₂O / 12 h / Ambient temperature

5: 67 percent / hydrogen / Pd/C / ethanol / 1 h

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; 2,2,4-trimethylpentane; ethanol; dichloromethane;
DOI:10.1021/jo00023a028

Reference yield:

: 80541-31-7
2,2-dimethyl-4-(2-furyl)hydroxymethyl-1,3-dioxolane

: 136089-35-5
<2R-<2α(R),6β>>-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-6-methoxy-6-<(phenylmethoxy)methyl>-2,4-dihydro-5H-pyran-3(6H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 8 h / Ambient temperature

2: 1.) t-BuLi / 1.) THF, 0 deg C, 4 h, 2.) r.t., 10 h

3: n-Bu₄NF / tetrahydrofuran / 8 h / Ambient temperature

4: 91 percent / t-BuOOH, VO(acac)2 / CH₂Cl₂; 2,2,4-trimethyl-pentane / Ambient temperature

5: 67 percent / Ag₂O / 12 h / Ambient temperature

6: 67 percent / hydrogen / Pd/C / ethanol / 1 h

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; 2,2,4-trimethylpentane; ethanol; dichloromethane;
DOI:10.1021/jo00023a028