3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

Base Information

Chemical Name:3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine
CAS No.:145576-86-9
Molecular Formula:C₂₇H₃₃NO₅Se
Molecular Weight:530.523
Hs Code.:

Synonyms:3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

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Chemical Property of 3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

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Technology Process of 3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

There total 5 articles about 3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 71338-47-1
2-phenylselenoacetaldehyde diethylacetal

: 174743-95-4
tert-Butyl 2-<(benzyloxycarbonyl)amino>-5-hydroxyhept-6-enoate

: 145576-86-9
3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

Guidance literature:: With pyridinium p-toluenesulfonate; for 4h; Heating;
DOI:10.1016/S0040-4039(00)61794-X

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 145576-86-9
3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / conc. H₂SO₄ / 16 h / Ambient temperature

2: 89 percent / t-BuOK / tetrahydrofuran / 1.) r.t., 15 min, 2.) r.t., 1 h

3: 61 percent / tetrahydrofuran / 2 h / -78 °C

4: 95 percent / NaBH₄, CeCl₃*7H₂O / methanol / 0.25 h / -20 °C

5: 72 percent / PPTS / toluene / 2 h / Heating

With sodium tetrahydroborate; cerium(III) chloride; sulfuric acid; potassium tert-butylate; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1039/p19960000123

Reference yield:

: 85136-12-5
(+/-)-tert-butyl 5-oxopyrrolidine-2-carboxylate

: 145576-86-9
3-Benzyloxycarbonyl-4-(tert-butoxycarbonyl)-2-phenylselanyl-7-vinyl-hexamethylhydro-1,3-oxazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / t-BuOK / tetrahydrofuran / 1.) r.t., 15 min, 2.) r.t., 1 h

2: 61 percent / tetrahydrofuran / 2 h / -78 °C

3: 95 percent / NaBH₄, CeCl₃*7H₂O / methanol / 0.25 h / -20 °C

4: 72 percent / PPTS / toluene / 2 h / Heating

With sodium tetrahydroborate; cerium(III) chloride; potassium tert-butylate; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1039/p19960000123