{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

Base Information

• Chemical Name: {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane
• CAS No.: 158040-52-9
• Molecular Formula: C₃₄H₅₈O₄S₂Si
• Molecular Weight: 623.05
• Mol file: 158040-52-9.mol

Synonyms:{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

Chemical Property of {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

There total 2 articles about {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + tert-Butyl-{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-diphenyl-silane (128716-86-9) → {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane (158040-52-9)

Guidance literature:

With sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1016/S0040-4039(00)73331-4

Reference yield:

Trifluoro-methanesulfonic acid (2S,3S)-1-[1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-meth-(Z)-ylidene]-3-[1,3]dithian-2-yl-2-(4-methoxy-benzyloxy)-butyl ester (128716-87-0) → {(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane (158040-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / CuI / diethyl ether / 0 °C

2: 81 percent / NaH / hexamethylphosphoric acid triamide

With copper(l) iodide; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;

DOI:10.1016/S0040-4039(00)73331-4

Reference yield: 74.0%

{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane (158040-52-9) + (E)-(4R,8S,10S,11R,12S,14R)-11-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-iodo-ethyl]-10,12,15,15-tetramethoxy-6,8,14-trimethyl-pentadeca-1,5-diene (158040-51-8) → C70H130O10S2Si3

Guidance literature:

With tert.-butyl lithium; 1.) THF, HMPA, -78 deg C; 2.) THF, -78 deg C, 30 min;

DOI:10.1016/S0040-4039(00)73331-4

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate

tert-Butyl-{(1R,2R,4R)-4-[(E)-(3S,4S)-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-2-methyl-pent-1-enyl]-2-methoxy-cyclohexyloxy}-diphenyl-silane

Trifluoro-methanesulfonic acid (2S,3S)-1-[1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-meth-(Z)-ylidene]-3-[1,3]dithian-2-yl-2-(4-methoxy-benzyloxy)-butyl ester

Downstream raw materials:

C₆₈H₁₃₈O₁₀Si₄